NpgRJ_Nn_1858 301..310
نویسندگان
چکیده
Dendritic spines are small protrusions emerging from dendrites that receive excitatory input. The process of spine morphogenesis occurs both in the developing brain and during synaptic plasticity. Molecules regulating the cytoskeleton are involved in spine formation and maintenance. Here we show that reverse signaling by the transmembrane ligands for Eph receptors, ephrinBs, is required for correct spine morphogenesis. The molecular mechanism underlying this function of ephrinBs involves the SH2 and SH3 domain–containing adaptor protein Grb4 and the G protein–coupled receptor kinase–interacting protein (GIT) 1. Grb4 binds by its SH2 domain to Tyr392 in the synaptic localization domain of GIT1. Phosphorylation of Tyr392 and the recruitment of GIT1 to synapses are regulated by ephrinB activation. Disruption of this pathway in cultured rat hippocampal neurons impairs spine morphogenesis and synapse formation. We thus show an important role for ephrinB reverse signaling in spine formation and have mapped the downstream pathway involved in this process.
منابع مشابه
Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3
The human zona pellucida glycoprotein-3 (hZP3) by virtue of its critical role during fertilization has been proposed as a promising candidate antigen to develop a contraceptive vaccine. In this direction, it is imperative to map minimal motifs of the B cell epitopes (BCEs) so as to avoid ZP-specific oophoritogenic T cell epitopes (TCEs) in the ZP3-based immunogens. In this study, based on known...
متن کاملIsomeric fatty acids.
Tipping, E. & Ketterer. B. (1981) Biochem. J . 195. 441-452 Van Der Vusse, G. J.. Roemen, T. H. M., Flameng, W. & Reneman. R. S. (1983) Biochim. Eiophvs. Acta 752. 361---370 Veerkamp, J. H. & Van Moerkerk. H. T. B. (1986) Biochim. Biophys. Acta 875, 301-310 Veerkamp, J . H., Van Moerkerk, H. T. B.. Glatz, J . F. C. & Van Hinsbergh, V. W. M. (1983) Biochim. Biophy.r. Acia 753. 399 410 Weisiger, ...
متن کاملNew Cancer Therapies for the 21st Century: A Two Decade Review of Approved Drugs and Drugs in Development in the United States
New Cancer Therapies for the 21st Century: A Two Decade Review of Approved Drugs and Drugs in Development in the United States Erlinda M. Gordon1,2*, Neal S. Chawla1 , Frederick L. Hall2, Sant P. Chawla1 1Cancer Center of Southern California/Sarcoma Oncology Center, Santa Monica CA 90403 2Counterpoint Biomedica LLC, Santa Monica, CA 90405 *Corresponding author: Dr. Erlinda M. Gordon, M.D. , Dir...
متن کاملA Simplified Method for Auxin Extraction.
1 Some of the results are briefly described in Bull. Amer. Math. Soc., abstracts 43-3114, 43-3-209, 43-9-323. There are two errors of statement in the first abstract: on page 171, line 1, the symbols "C" should be replaced by "D" and on page 171, line 2, "H(W)" should be replaced by "H(W)." 2 M. H. Stone, Linear Transformations in Hilbert Space, New York, 1932, 424-530, especially Theorems 10.7...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007